American Journal of Preventive Medicine
Volume 35, Issue 6 , Pages 572-577 , December 2008

Economic Evaluation of a Neural Tube Defect Recurrence–Prevention Program

  • Scott D. Grosse, PhD

      Affiliations

    • National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia
    • Corresponding Author InformationAddress correspondence and reprint requests to: Scott D. Grosse, PhD, CDC, 1600 Clifton Road, MS E-87, Atlanta GA 30333
    • ,
  • Lijing Ouyang, PhD

      Affiliations

    • National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia
    • ,
  • Julianne S. Collins, PhD

      Affiliations

    • Greenwood Genetic Center, Greenwood, South Carolina
    • ,
  • Denise Green, MPH

      Affiliations

    • National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia
    • ,
  • Jane H. Dean, RN

      Affiliations

    • Greenwood Genetic Center, Greenwood, South Carolina
    • ,
  • Roger E. Stevenson, MD

      Affiliations

    • Greenwood Genetic Center, Greenwood, South Carolina

References 

  1. Medical Research Council Vitamin Study Research Group. Prevention of neural tube defects: results of the medical research council vitamin study. Lancet. 1991;338:131–137
  2. Rowland CA, Correa A, Cragan JD, Alverson CJ. Are encephaloceles neural tube defects?. Pediatrics. 2006;118:916–923
  3. Little J. Risks in siblings and other relatives. In:  Elwood JM,  Little J,  Elwood JH editor. Epidemiology and control of neural tube defects. Oxford: Oxford University Press; 1992;p. 604–676
  4. Grosse SD, Collins JS. Folic acid supplementation and neural tube defect recurrence prevention. Birth Def Res Part A. 2007;79:737–742
  5. Dean JH, Collins JS, Clary NJ, Stevenson RE. Preventing the recurrence of neural tube defects in South Carolina. Proc Greenwood Genet Center. 2007;26:40–44
  6. Felkner M, Suarez L, Hendricks K, Larsen R. Implementation and outcomes of recommended folic acid supplementation in Mexican-American women with prior neural tube defect-affected pregnancies. Prev Med. 2005;40:867–871
  7. Vergel RG, Sanchez LR, Heredero BL, et al. Primary prevention of neural tube defects with FA supplementation: Cuban experience. Prenat Diagn. 1990;10:149–152
  8. CDC. Use of folic acid for prevention of spina bifida and other neural tube defects—1983–1991. MMWR Morb Mortal Wkly Rep. 1991;40:513–516
  9. CDC. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm Rep. 1992;41:1–7
  10. CDC. Use of vitamins containing folic acid among women of childbearing age—U.S., 2007. MMWR Morb Mortal Wkly Rep. 2008;57:5–8
  11. Canfield MA, Anderson JL, Waller DK, et al. Folic acid awareness and use among women with a history of a neural tube defect pregnancy—Texas, 2000–2001. MMWR Recomm Rep. 2002;51:16–19
  12. Callender ES, Rickard R, Miller L, Rinsky-Eng J. Knowledge and use of folic acid supplementation: a study of Colorado women whose pregnancies were affected by a fetal neural tube defect. Clin Invest Med. 2001;24:124–128
  13. Stevenson RE, Allen WP, Pai GS, et al. Decline in prevalence of neural tube defects in a high-risk region of the U.S.. Pediatrics. 2000;106:677–683
  14. U.S. Bureau of Labor Statistics. Employment cost trends. www.bls.gov/ncs/ect/#tables
  15. Bol KA, Collins JS, Kirby RS National Birth Defects Prevention Network. Survival of infants with neural tube defects in the presence of folic acid fortification. Pediatrics. 2006;117:803–813
  16. Gold MR, Siegel JE, Russell LB, Weinstein MC. Cost-effectiveness in health and medicine. New York: Oxford University Press; 1996;
  17. Luce BR, Manning WG, Siegel JE, Lipscomb J. Estimating costs in cost-effectiveness analysis. In:  Gold MR,  Siegel JE,  Russell LB,  Weinstein MC editor. Cost-effectiveness in health and medicine. New York: Oxford University Press; 1996;
  18. Harris RA, Washington AE, Nease RF, Kuppermann M. Cost utility of prenatal diagnosis and the risk-based threshold. Lancet. 2004;363:276–282
  19. CDC. Hospital stays, hospital charges, and in-hospital deaths among infants with selected birth defects—U.S., 2003. MMWR Morb Mortal Wkly Rep. 2007;56:25–29
  20. Russo CA, Elixhauser A. Hospitalizations for birth defects, 2004 (HCUP Statistical Brief #24). Rockville MD: U.S. Agency for Healthcare Research and Quality; 2007;www.hcup-us.ahrq.gov
  21. Waitzman NJ, Scheffler RM, Romano PS. The costs of birth defects: estimates of the value of prevention. Lanham MD: University Press of America, Inc; 1996;
  22. Waitzman NJ, Romano PS, Grosse SD. Half-life of cost of illness estimates: the case of spina bifida. In:  Wyszynski DF editors. Neural tube defects: from origin to treatment. New York: Oxford University Press; 2005;
  23. Grosse SD, Waitzman NJ, Romano PS, Mulinare J. Reevaluating the benefits of folic acid fortification in the U.S.: economic analysis, regulation, and public health. Am J Public Health. 2005;95:1917–1922
  24. Ouyang L, Grosse SD, Armour BS, Waitzman NJ. Health care expenditures of children and adults with spina bifida in a privately insured U.S. population. Birth Def Res Part A. 2007;79:552–558
  25. Tilford JM, Grosse SD, Goodman AC, Li K. Labor market productivity costs for caregivers of children with spina bifida: a population-based analysis. Med Decis Making. 2008;Aug 25. [Epub ahead of print]
  26. Shepard CW, Ortega-Sanchez IR, Scott RD, et al. Cost-effectiveness of conjugate meningococcal vaccination strategies in the U.S.. Pediatrics. 2005;115:1220–1232
  27. Tilford JM, Grosse SD, Robbins JM, et al. Health state preference scores of children with spina bifida and their caregivers. Qual Life Res. 2005;14:1087–1098
  28. Kelly AE, Haddix AC, Scanlon KS, Helmick CG, Mulinare J. Cost-effectiveness of strategies to prevent neural tube defects. In:  Gold MR,  Siegel JE,  Russell LB,  Weinstein MC editor. Cost-effectiveness in health and medicine. New York: Oxford University Press; 1996;
  29. Forrester MB, Merz RD. Precurrence risk of neural tube defects in siblings of infants with lipomyelomeningocele. Genet Med. 2005;7:457
  30. Rinsky-Eng J, Miller L. Knowledge, use, and education regarding folic acid supplementation: continuation study of women in Colorado who had a pregnancy affected by a neural tube defect. Teratology. 2002;66(1S):S29–S31
  31. Grosse SD, Teutsch SM, Haddix AC. Lessons from cost-effectiveness research for U.S. public health policy. Annu Rev Public Health. 2007;28:365–391
  32. Grosse SD. Assessing cost effectiveness in health care: the history of the $50,000 per QALY threshold. Exp Rev Pharmacoeconomics Outcome Res. 2008;8:165–178
  33. Braithwaite RS, Meltzer D, King JT, Leslie D, Roberts MS. What does the value of modern medicine say about the $50,000 per quality-adjusted life-year decision rule?. Med Care. 2008;46:349–356
  34. Weinstein MC. How much are Americans willing to pay for a quality-adjusted life year?. Med Care. 2008;46:343–345
  35. Maciosek MV, Coffield AB, Edwards NM, Flottemesch TJ, Goodman MJ, Solberg LI. Priorities among effective clinical preventive services: results of a systematic review and analysis. Am J Prev Med. 2006;31:52–61
  36. Romano PS, Waitzman NJ, Scheffler RM, Pi RD. Folic acid fortification of grain: an economic analysis. Am J Public Health. 1995;85:667–676
  37. Postma MJ, Londeman J, Veenstra M, de Jong LT. Cost-effectiveness of periconceptual supplementation of folic acid. Pharm World Sci. 2002;24:8–11
  38. Llanos A, Hertrampf E, Cortes F, Pardo A, Grosse SD, Uauy R. Cost-effectiveness of a folic acid fortification program in Chile. Health Policy. 2007;83:295–303
  39. Committee on Medical Aspects of Food and Nutrition Policy (COMA). Folic acid and the prevention of disease. London: The Stationery Office; 2000;
  40. Istituto Superiore di Sanità. Folic acid: from research to public health practice. Edited by Domenica Taruscio. Rome. Rapporti ISTISAN 04/26, 2004. Istituto Superiore della Sanita, Rome. ISSN 1123-31127 www.iss.it/binary/acid/cont/ISTISAN%2004-26.1151073536.pdf

PII: S0749-3797(08)00736-8

doi: 10.1016/j.amepre.2008.07.008

American Journal of Preventive Medicine
Volume 35, Issue 6 , Pages 572-577 , December 2008

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