Background
Prior studies of the relationship of physical activity to osteoarthritis (OA) of the
knee have shown mixed results. The objective of this study was to determine if differences
in the progression of knee OA in middle- to older-aged runners exist when compared
with healthy nonrunners over nearly 2 decades of serial radiographic observation.
Methods
Forty-five long-distance runners and 53 controls with a mean age of 58 (range 50–72)
years in 1984 were studied through 2002 with serial knee radiographs. Radiographic
scores were two-reader averages for Total Knee Score (TKS) by modified Kellgren &
Lawrence methods. TKS progression and the number of knees with severe OA were compared
between runners and controls. Multivariate regression analyses were performed to assess
the relationship between runner versus control status and radiographic outcomes using
age, gender, BMI, education, and initial radiographic and disability scores among
covariates.
Results
Most subjects showed little initial radiographic OA (6.7% of runners and 0 controls);
however, by the end of the study runners did not have more prevalent OA (20 vs 32%,
p =0.25) nor more cases of severe OA (2.2% vs 9.4%, p=0.21) than did controls. Regression models found higher initial BMI, initial radiographic
damage, and greater time from initial radiograph to be associated with worse radiographic
OA at the final assessment; no significant associations were seen with gender, education,
previous knee injury, or mean exercise time.
Conclusions
Long-distance running among healthy older individuals was not associated with accelerated
radiographic OA. These data raise the possibility that severe OA may not be more common
among runners.
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Article Info
Publication History
Published online: June 13, 2008
Identification
Copyright
© 2008 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
