Background
Sedentary behavior is emerging as an independent risk factor for chronic disease;
however, potential mechanisms underpinning these observations are not well understood.
Purpose
This study aimed to investigate the association of self-reported weekday sitting time
with biomarkers linked to chronic low-grade inflammation, insulin resistance, and
adiposity.
Methods
This study reports data from individuals attending a diabetes screening program, United
Kingdom, 2004–2007; analysis was conducted in 2010. Sitting time and physical activity
were measured using the International Physical Activity Questionnaire; biochemical
outcomes included fasting and 2-hour postchallenge glucose, fasting insulin, C-reactive
protein (CRP), leptin, adiponectin, and interleukin-6 (IL-6).
Results
This study included 505 (female=46%; South-Asian ethnicity=19%, aged 59±10 years,
BMI=29.5±4.7) individuals with valid sitting data. Increased sitting time was positively
associated with fasting insulin, leptin, leptin/adiponectin ratio, CRP, and IL-6 in
women, but not men, after adjustment for age, ethnicity, social deprivation, and smoking
and medication status; interaction analysis revealed that the gender-specific differences
were significant. The associations for women remained significant after additional
adjustment for total moderate- to vigorous-intensity physical activity; however all
associations were attenuated when further adjusted for BMI. There was no association
between sitting time and glycemic status.
Conclusions
Total self-reported weekday sitting time was associated with biomarkers linked to
chronic low-grade inflammation and poor metabolic health in women, but not men, independent
of physical activity.
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References
- Deleterious associations of sitting time and television viewing time with cardiometabolic risk biomarkers: Australian Diabetes, Obesity and Lifestyle (AusDiab) study 2004−2005.Diabetes Care. 2010; 33: 327-334
- Associations of TV viewing and physical activity with the metabolic syndrome in Australian adults.Diabetologia. 2005; 48: 2254-2261
- Physical activity and television viewing in relation to risk of undiagnosed abnormal glucose metabolism in adults.Diabetes Care. 2004; 27: 2603-2609
- Sitting time and mortality from all causes, cardiovascular disease, and cancer.Med Sci Sports Exerc. 2009; 41: 998-1005
- Television viewing time and mortality: the Australian Diabetes, Obesity and Lifestyle study (AusDiab).Circulation. 2010; 121: 384-391
- Television viewing time independently predicts all-cause and cardiovascular mortality: the EPIC Norfolk study.Int J Epidemiol. 2011; 40: 1509
Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1008;41:1241–8.
- A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?.Diabetes. 2005; 54: 917-927
- Leptin beyond weight regulation—current concepts concerning its role in immune function and inflammation.Cell Immunol. 2008; 252: 139-145
- Does physical activity energy expenditure explain the between-individuals variation in plasma leptin concentrations after adjustment for differences in body composition.J Clin Endocrinol. 2003; 88: 3258-3263
- The associations between leisure-time physical activity and inflammatory and coagulation markers related to cardiovascular disease: the ATTICA Study.Prev Med. 2005; 40: 432-437
- Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study.Diabetologia. 2009; 52: 433-442
- The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review.J Am Coll Cardiol. 2005; 45: 1563-1569
- Rationale and design of the ADDITION-Leicester study, a systematic screening programme and randomised controlled trial of multi-factorial cardiovascular risk intervention in people with type 2 diabetes mellitus detected by screening.Trials. 2010; 11: 16
- International Physical Activity Questionnaire: 12-country reliability and validity.Med Sci Sports Exerc. 2003; 35: 1381-1395
- The English Indices of Deprivation 2007: summary.
- Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals.Diabetologia. 2009; 52: 2345-2349
- Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery.Stroke. 2007; 38: 2844-2846
- Measuring total and domain-specific sitting: a study of reliability and validity.Med Sci Sports Exerc. 2010; 42: 1094-1102
- Limits to the measurement of habitual physical activity by questionnaires.Br J Sports Med. 2003; 37: 197-206
- Validity of two self-report measures of sitting time.J Phys Act Health. 2011; (published ahead of print)
- Association of television viewing with fasting and 2-h postchallenge plasma glucose levels in adults without diagnosed diabetes.Diabetes Care. 2007; 30: 516-522
- Leisure time spent sitting in relation to total mortality in a prospective cohort of U.S. adults.Am J Epidemiol. 2010; 172: 419-429
- Associations between dietary patterns, physical activity (leisure-time and occupational) and television viewing in middle-aged French adults.Br J Nutr. 2011; 105: 902-910
- Sedentary behaviour and dietary intake in children, adolescents, and adults.Am J Prev Med. 2011; 41: 178-188
- Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease.Diabetes. 2007; 56: 2655-2667
- Percent body fat and lean mass explain the gender difference in leptin: analysis and interpretation of leptin in Hispanic and non-Hispanic white adults.Obes Res. 2000; 8: 543-552
- Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.J Clin Endocrinol Metab. 1997; 82: 4196-4200
- Sedentary behaviours and subsequent health outcomes in adults: a systematic review of longitudinal studies.Am J Prev Med. 2011; 41: 207-215
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© 2012 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.