Background
Sedentary behavior is emerging as an independent risk factor for chronic disease;
however, potential mechanisms underpinning these observations are not well understood.
Purpose
This study aimed to investigate the association of self-reported weekday sitting time
with biomarkers linked to chronic low-grade inflammation, insulin resistance, and
adiposity.
Methods
This study reports data from individuals attending a diabetes screening program, United
Kingdom, 2004–2007; analysis was conducted in 2010. Sitting time and physical activity
were measured using the International Physical Activity Questionnaire; biochemical
outcomes included fasting and 2-hour postchallenge glucose, fasting insulin, C-reactive
protein (CRP), leptin, adiponectin, and interleukin-6 (IL-6).
Results
This study included 505 (female=46%; South-Asian ethnicity=19%, aged 59±10 years,
BMI=29.5±4.7) individuals with valid sitting data. Increased sitting time was positively
associated with fasting insulin, leptin, leptin/adiponectin ratio, CRP, and IL-6 in
women, but not men, after adjustment for age, ethnicity, social deprivation, and smoking
and medication status; interaction analysis revealed that the gender-specific differences
were significant. The associations for women remained significant after additional
adjustment for total moderate- to vigorous-intensity physical activity; however all
associations were attenuated when further adjusted for BMI. There was no association
between sitting time and glycemic status.
Conclusions
Total self-reported weekday sitting time was associated with biomarkers linked to
chronic low-grade inflammation and poor metabolic health in women, but not men, independent
of physical activity.
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© 2012 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
