- Maron B.J.
- Thompson P.D.
- Ackerman M.J.
- et al.
- Maron B.J.
- Thompson P.D.
- Ackerman M.J.
- et al.
|1. Exertional chest pain/discomfort|
| 2. Unexplained syncope/near-syncope
|3. Excessive exertional and unexplained dyspnea/fatigue, associated with exercise|
|4. Prior recognition of a heart murmur|
|5. Elevated systemic blood pressure|
|6. Premature death (sudden and unexpected, or otherwise) before age 50 years due to heart disease, in ≥1 relative|
|7. Disability from heart disease in a close relative aged <50 years|
|8. Specific knowledge of certain cardiac conditions in family members: hypertrophic or dilated cardiomyopathy, long-QT syndrome or other ion channelopathies, Marfan syndrome, or clinically important arrhythmias|
| 9. Heart murmur
|10. Femoral pulses to exclude aortic coarctation|
|11. Physical stigmata of Marfan syndrome|
|12. Brachial artery blood pressure (sitting position)|
|Epidemiology and etiology of SCDY|
|Develop an SCDY registry to prospectively estimate the incidence of SCDY|
|Perform case–control studies using registry-defined cases to identify risk factors for SCDY|
|Performance of the screening methodology in the target population|
|Perform pilot ECG screening studies to test the characteristics of the ECG in target populations|
|Perform comparative effectiveness studies to determine the incremental value of various screening methodologies, including history and physical examination, ECG, echocardiogram, and genetic testing|
|Management of asymptomatic heart disease identified by ECG screening|
|Develop evidence-based management strategies for asymptomatic patients|
|Evaluate risk stratification, prevention, and therapeutic strategies|
|Use novel study designs and innovative recruitment strategies when studying low-prevalence diseases|
|Impact of a screening program|
|Evaluate the impact of a screening program on individuals and families using quality-of-life studies and patient-preference measurements|
|Use decision analysis to evaluate overall effectiveness of a screening program, as well as cost and resource utilization|
|Other resources to facilitate research|
|Redefine the diagnostic criteria for the long-QT syndrome in the genetic era|
|Define ECG norms in the U.S. population, taking into account demographic variability|
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