Major vaccine safety controversies have arisen in several countries beginning in the
last decades of 20th century. Such periodic vaccine safety controversies are unlikely
to go away in the near future as more national immunization programs mature with near
elimination of target vaccine-preventable diseases that result in relative greater
prominence of adverse events following immunizations, both true reactions and temporally
coincidental events. There are several ways in which vaccine safety capacity can be
improved to potentially mitigate the impact of future vaccine safety controversies.
This paper aims to take a “lifecycle” approach, examining some potential pre- and
post-licensure opportunities to improve vaccine safety, in both developed (specifically
U.S. and Europe) and low- and middle-income countries.
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