Introduction
An important barrier to formulating effective policies to address the rapid rise in
U.S. fatal overdoses is that the specific drugs involved are frequently not identified
on death certificates. This analysis supplies improved estimates of state opioid and
heroin involved drug fatality rates in 2014, and changes from 2008 to 2014.
Methods
Reported mortality rates were calculated directly from death certificates and compared
to corrected rates that imputed drug involvement when no drug was specified. The analysis
took place during 2016–2017.
Results
Nationally, corrected opioid and heroin involved mortality rates were 24% and 22%
greater than reported rates. The differences varied across states, with particularly
large effects in Pennsylvania, Indiana, and Louisiana. Growth in corrected opioid
mortality rates, from 2008 to 2014, were virtually the same as reported increases
(2.5 deaths per 100,000 people) whereas changes in corrected heroin death rates exceeded
reported increases (2.7 vs 2.3 per 100,000). Without corrections, opioid mortality
rate changes were considerably understated in Pennsylvania, Indiana, New Jersey, and
Arizona, but dramatically overestimated in South Carolina, New Mexico, Ohio, Connecticut,
Florida, and Kentucky. Increases in heroin death rates were understated in most states,
and by large amounts in Pennsylvania, Indiana, New Jersey, Louisiana, and Alabama.
Conclusions
The correction procedures developed here supply a more accurate understanding of geographic
differences in drug poisonings and supply important information to policymakers attempting
to reduce or slow the increase in fatal drug overdoses.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of Preventive MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Increase in drug and opioid overdose deaths – United States, 2000-2014.MMWR Morb Mortal Wkly Rep. 2016; 64: 1378-1382https://doi.org/10.15585/mmwr.mm6450a3
- Drug poisoning deaths in the United States, 1980–2008. NCHS Data Brief, no 81.National Center for Health Statistics, Hyattsville, MD2011 (https://doi.org/10.1073/pnas.1518393112)
- Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century.Proc Natl Acad Sci U S A. 2015; 112: 15078-15083https://doi.org/10.1073/pnas.1518393112
- Vital Signs: Overdoses of prescription opioid pain relievers - United States, 1999–2008.MMWR Morb Mortal Wkly Rep. 2011; 60: 1487-1492
- Vital Signs: Risk for overdose from methadone used for pain relief – United States, 1999-2010.MMWR Morb Mortal Wkly Rep. 2012; 61: 493-497
- Medication-assisted therapies – tackling the opioid overdose epidemic.N Engl J Med. 2014; 370: 2063-2066https://doi.org/10.1056/NEJMp1402780
- Vital signs: demographic and substance use trends among heroin users—United States, 2002–2013.MMWR Morb Mortal Wkly Rep. 2015; 64: 719-725
- White House Summit on the Opioid Epidemic.Office of National Drug Policy, Washington DCJune 19, 2014 (Accessed June 27, 2017)
- Opioids drive continued increase in drug overdose deaths. 2013; (Accessed June 27, 2017)
- Prescription drug monitoring programs.Library of Congress, Congressional Research Service, Washington, DC2013 (Accessed June 27, 2017)
- Testimony for “Curbing Prescription Drug Abuse in Medicare”.Hearing before the Committee on Homeland Security and Governmental Affairs, United States Senate, 113th Congress. 2013; (Accessed June 27, 2017)
- Prescription drug abuse: executive summary of a policy position paper from the American College of Physicians.Ann Intern Med. 2014; 160: 198-200https://doi.org/10.7326/M13-2209
- Prescription drug monitoring programs and death rates from drug overdose.Pain Med. 2011; 12: 747-754https://doi.org/10.1111/j.1526-4637.2011.01062.x
- Can prescription drug monitoring programs help limit opioid abuse?.JAMA. 2011; 306: 2258-2259https://doi.org/10.1001/jama.2011.1712
- Prescription drug monitoring and drug overdose mortality.Inj Epidemiol. 2014; 1: 1-8https://doi.org/10.1186/2197-1714-1-1
- Hal Jonson Consulting, Division of Disease Control and Health Promotion, Florida Department of Health. Decline in drug overdose deaths after state policy changes – Florida, 2010-2012.MMWR Morb Mortal Wkly Rep. 2014; 63: 569-574
- Drug involvement in fatal overdoses.SSM Popul Health. 2017; 3: 219-226https://doi.org/10.1016/j.ssmph.2017.01.009
- Drug overdose deaths: let’s get specific.Public Health Rep. 2015; 130: 339-342https://doi.org/10.1177/003335491513000411
- Stateline: getting better data on which drugs are killing people.Pew Charitable Trusts. August 19, 2016; (Accessed November 1, 2016)
- Drug poisoning deaths in the United States, 1999-2012: a statistical adjustment analysis.Popul Health Metr. 2016; 14: 2https://doi.org/10.1186/s12963-016-0071-7
- Trends and geographic patterns in drug-poisoning death rates in the U.S., 1999–2009.Am J Prev Med. 2013; 45: e19-e25https://doi.org/10.1016/j.amepre.2013.07.012
- Drug poisoning mortality: United States, 1999–2014. National Center for Health Statistics. 2016; (Accessed November 2, 2016)
CDC. Multiple cause of death, 1999–2014. http://wonder.cdc.gov/wonder/help/mcd.html. Accessed June 15, 2016.
- International Statistical Classification of Diseases and Related Health Problems, ICD-10. 10th Revised. WHO, Geneva2012
National Cancer Institute. Surveillance, Epidemiology, and End Results Program. www.seer.cancer.gov/resources. Accessed August 4, 2016.
- State variation in certifying manner of death and drugs involved in drug intoxication deaths.Acad Forensic Pathol. 2013; 3: 231-237
- Obtaining adequate data to determine causes of opioid-related overdose deaths.Pain Med. 2011; 12: S86-S92https://doi.org/10.1111/j.1526-4637.2011.01132.x
- Uniform standards and case definitions for classifying opioid-related deaths: recommendations by a SAMHSA Consensus Panel.J Addict Dis. 2013; 32: 231-243https://doi.org/10.1080/10550887.2013.824334
- Comprehensive Addiction and Recovery Act of 2016, Pub. L. No: 114-198, 130 Stat. 695. 2016; (Accessed November 2, 2016)
- President Obama proposes $1.1 billion in new funding to address the prescription opioid abuse and heroin use epidemic.J Pain Palliat Care Pharmacother. 2016; 30: 134-137https://doi.org/10.3109/15360288.2016.1173760
- Even as mortality fell in most U.S. counties, female mortality nonetheless rose in 42.8 percent of counties from 1992 to 2006.Health Aff (Millwood). 2013; 32: 451-458https://doi.org/10.1377/hlthaff.2011.0892
- Losing ground at midlife in America.Proc Natl Acad Sci U S A. 2015; 112: 15006-15007https://doi.org/10.1073/pnas.1519763112
- State legal restrictions and prescription-opioid use among disabled adults.N Engl J Med. 2016; 375: 44-53https://doi.org/10.1056/NEJMsa1514387
- Medicaid Coverage and Financing of Medications to Treat Alcohol and Opioid Disorders. HHS Publication No. SMA-14-4854.Substance Abuse and Mental Health Services Administration, Rockville, MD2014
- Data Analysis Using Regression and Multilevel/Hierarchical Models.Cambridge University Press, New York2006 (http://dx.doi.org/10.1017/CBO9780511790942)
- Macroeconomic conditions and opioid abuse.NBER Work Pap Ser. 2017; : 23192https://doi.org/10.3386/w23192
- Underrepresentation of heroin involvement in unintentional drug overdose deaths in Allegheny County, PA.J Forensic Sciences. 2014; 59: 1583-1585https://doi.org/10.1111/1556-4029.12541
- Identifying cases of heroin toxicity where 6-acetylmorphine (6-AM) is not detected by toxicological analyses.Forensic Sci Med Pathol. 2016; 12: 243-247https://doi.org/10.1007/s12024-016-9780-2
Article Info
Publication History
Published online: August 07, 2017
Identification
Copyright
© 2017 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.