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Health of Transgender Adults in the U.S., 2014–2016

  • Janelle M. Downing
    Correspondence
    Address correspondence to: Janelle M. Downing, PhD, 915 Greene Street #349, Arnold School of Public Health, University of South Carolina, Columbia SC 29208
    Affiliations
    Health Services Policy and Management, School of Public Health, University of South Carolina, Columbia, South Carolina
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  • Julia M. Przedworski
    Affiliations
    Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, Minnesota

    School of Nursing, Oregon Health & Science University, Portland, Oregon
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Open AccessPublished:July 18, 2018DOI:https://doi.org/10.1016/j.amepre.2018.04.045

      Introduction

      Transgender people experience significant interpersonal and structural discrimination and stigma. However, little is known about the health of transgender people, and even less about the health of specific groups—including male-to-female, female-to-male, and gender-nonconforming transgender populations—despite the variation in social and biological characteristics across groups.

      Methods

      Data are from the 2014–2016 Behavioral Risk Factor Surveillance System, analyzed in 2017. The study population included 2,221 transgender and 523,080 cisgender respondents from 31 states and one territory. The authors estimated the prevalence and adjusted odds of chronic health conditions, health-related quality of life, disabilities, health behaviors, and health utilization among three transgender groups, when compared separately with cisgender males and cisgender females.

      Results

      An estimated 0.24% (95% CI=0.21, 0.27) identified as male-to-female; 0.14% (95% CI=0.12, 0.17) identified as female-to-male; and 0.10% (95% CI=0.08, 0.12) identified as gender-nonconforming. All transgender groups experience worse mental health and disabilities; few differences in healthcare access and utilization were observed. Gender-nonconforming people had higher odds of multiple chronic conditions, poor quality of life, and disabilities than both cisgender males and females. Female-to-male people had a higher odds of no exercise and cardiovascular disease compared with cisgender females.

      Conclusions

      Given the high burden of disabilities; poor mental health; and multiple chronic conditions among transgender (particularly gender-nonconforming) populations, supportive services and care coordination may be consequential levers for improving transgender health.

      Introduction

      Transgender and gender-nonconforming people (TGNC; people who do not identify with their assigned sex at birth, i.e., gender-minority people) experience interpersonal, structural, and cultural discrimination that has significant negative effects on their physical and mental health. This study contributes to the emerging evidence base on gender-minority health disparities, and is responsive to the National Academy of Medicine’s (formerly known as the Institute of Medicine) 2011 call for an expansion of all aspects of the evidence base for gender-minority health, given the scarcity of relevant research.
      • Graham R.
      • Berkowitz B.
      • Blum R.
      • et al.
      The Health of Lesbian, Gay, Bisexual, and Transgender People: Building a Foundation for Better Understanding.
      This study seeks to address three limitations of the existing literature. First, it uses nationally representative, population-level data that are generalizable beyond the sampling frame. Most prior research used clinical samples, which exclude transgender people who do not seek gender-confirming health care, or community samples that do not generalize across place. One population-level study using the Massachusetts Behavioral Risk Factor Surveillance (BRFSS) found few differences in health by gender identity.
      • Conron K.J.
      • Scott G.
      • Stowell G.S.
      • Landers S.J.
      Transgender health in Massachusetts: results from a household probability sample of adults.
      A larger, 2014 BRFSS study of 19 states found that compared with cisgender individuals (those who identify with their assigned sex at birth), transgender individuals had worse general health and more days of poor physical and mental health, yet no differences were observed in the prevalence of chronic illness and health behaviors.
      • Meyer I.H.
      • Brown T.N.
      • Herman J.L.
      • Reisner S.L.
      • Bockting W.O.
      Demographic characteristics and health status of transgender adults in select U.S. regions: Behavioral Risk Factor Surveillance System, 2014.
      These population-level findings, although limited by small sample sizes, found fewer health disparities than studies using community and clinical samples, which documented high rates of psychological distress, HIV, sexually transmitted infections, disabilities, and risky health behaviors among transgender populations.
      • Dragon C.N.
      • Guerino P.
      • Ewald E.
      • Laffan A.M.
      Transgender Medicare beneficiaries and chronic conditions: exploring fee-for-service claims data.
      Second, this study evaluates transgender health in domains that have previously been unexamined in the literature. These gaps are due, in part, to the absence of gender identity measures in national health surveillance,
      • Graham R.
      • Berkowitz B.
      • Blum R.
      • et al.
      The Health of Lesbian, Gay, Bisexual, and Transgender People: Building a Foundation for Better Understanding.
      as well as inadequate funding for transgender-specific health research: between 1989 and 2011, NIH funded only 43 transgender-specific studies, most of which focused on HIV-related health issues.
      • Coulter R.W.
      • Kenst K.S.
      • Bowen D.J.
      Scout. Research funded by the National Institutes of Health on the health of lesbian, gay, bisexual, and transgender populations.
      Nearly half of studies on transgender health from 2008 to 2014 included measures of mental health and substance abuse, whereas less than 7% of studies included general health conditions, such as diabetes and cancer.
      • Reisner S.L.
      • Poteat T.
      • Keatley J.
      • et al.
      Global health burden and needs of transgender populations: a review.
      Third, most extant population-level studies did not have adequate samples to examine the health of transgender subpopulations: transgender women (male-to-female, MTF); transgender men (female-to-male, FTM); and gender-nonconforming (GNC) people.
      • Collin L.
      • Reisner S.L.
      • Tangpricha V.
      • Goodman M.
      Prevalence of transgender depends on the “case” definition: a systematic review.
      This gap in the literature is significant, as the lived experiences of these populations can be markedly different, both in exposure to interpersonal and structural cissexism (discrimination and stigma against TGNC people), and the amount and quality of engagement with the healthcare system.
      • Meyer I.H.
      • Brown T.N.
      • Herman J.L.
      • Reisner S.L.
      • Bockting W.O.
      Demographic characteristics and health status of transgender adults in select U.S. regions: Behavioral Risk Factor Surveillance System, 2014.
      For example, the National Transgender Discrimination Survey found that GNC people faced more discrimination in medical care and worse health than other transgender groups.
      • Harrison J.
      • Grant J.
      • Herman J.L.
      A gender not listed here: genderqueers, gender rebels, and otherwise in the National Transgender Discrimination Survey.
      Prior research using the Massachusetts BRFSS suggested there were differences in the health of male- and female-sounding transgender respondents.
      • Conron K.J.
      • Scott G.
      • Stowell G.S.
      • Landers S.J.
      Transgender health in Massachusetts: results from a household probability sample of adults.
      Furthermore, few studies have compared transgender people with both cisgender males (CMs) and cisgender females (CFs).
      This study uses the most comprehensive sample of transgender adults in the U.S. to date, pooling data from 2014 to 2016 probability samples of 31 states and one territory. Because of the structural and interpersonal discrimination faced by transgender people,
      • Hughto J.M.W.
      • Reisner S.L.
      • Pachankis J.E.
      Transgender stigma and health: a critical review of stigma determinants, mechanisms, and interventions.
      and the resulting minority stress,
      • Meyer I.H.
      Minority stress and mental health in gay men.
      the study authors hypothesized that each transgender group would have worse outcomes, greater health risks, and lower healthcare access and utilization than cisgender people. As a result of variation in how gender identity was measured in prior studies, no ex-ante hypothesis exists for how and if the magnitude of differences vary across transgender groups.

      Methods

      This study used data from 2014, 2015, and 2016 BRFSS, an initiative by the Centers for Disease Control to collect state-specific data on behavioral and health factors among non-institutionalized adults using telephone (landline and cellular) survey methods. More than 400,000 interviews are completed each year. The median response rate was between 47.7% and 48.7% for landlines and 40.5% and 47.2% for cellular in included study years.
      Centers for Disease Control and Prevention (CDC)
      2014 Behavioral Risk Factor Surveillance System Survey Questionnaire.
      Centers for Disease Control and Prevention (CDC)
      2015 Behavioral Risk Factor Surveillance System Survey Questionnaire.
      Centers for Disease Control and Prevention (CDC)
      2016 Behavioral Risk Factor Surveillance System Survey Questionnaire.

       Study Sample

      The sample included data from residents of 31 states and one U.S. territory (Guam) that completed the sexual orientation and gender identity (SOGI) module during 2014–2016 (Figure 1). Ten states administered the SOGI module in all 3 years, 13 states and Guam in 2 years, and eight states in 1 year.
      Figure thumbnail gr1
      Figure 1Percent of state population identified as transgender using BRFSS 2014–2016.
      BRFSS, Behavioral Risk Factor Surveillance System.
      Compared with states that did not administer the SOGI, respondents in states with the SOGI module were more likely to be female, older, less non-Hispanic white, wealthier, have lower educational attainment, and be living with a partner and have at least one child in the household (Appendix Table 1, available online).

       Measures

      Respondents were asked: Do you consider yourself to be transgender? Those who responded yes were prompted to indicate male-to-female, female-to-male, gender-nonconforming, do not know, I’m not sure, or refused to answer (Appendix Figure 1, available online). Five measures of gender identity were created: transgender MTF, transgender FTM, and transgender GNC. Respondents who did not identify as transgender were considered CF if they were female sex, and CM if they were male sex. In 2014 and 2015, the sex of respondents was assigned by the interviewer based on the sound of participant voices. In 2016, sex was assessed by asking respondents, Are you male or female?
      Demographics included age; race/ethnicity (non-Hispanic white, non-Hispanic black, Hispanic, other/multiple); educational attainment (did not complete high school, high school graduate, some college/technical school, college/technical school graduate); income (<$15,000, $15,000–$24,999, $25,000–$34,999, $35,000–$49,999, ≥$50,000); employment status (employed, unemployed, not looking for work, retired, unable to work); health insurance; housing tenure (owner, renter, other arrangement); marital status (married/partnered, divorced/separated/widowed, single); presence of children in the household; and sexual orientation (heterosexual, lesbian/gay, bisexual).
      Five most prevalent chronic conditions (i.e., >10% of the sample) were included. Respondents were asked, Has a doctor, nurse, or other professional ever told you that you had any of the following: (1) coronary heart disease or myocardial infarction (CHD/MI), (2) asthma, (3) arthritis (some form of arthritis, rheumatoid arthritis, gout, lupus, or fibromyalgia), (4) diabetes (excluding pregnancy-related), or (5) depressive disorder (depression, major depression, dysthymia, or minor depression)? Respondents were classified as having multiple chronic conditions if they reported two or more of the prior five conditions; cancer (excluding skin cancer); stroke; chronic obstructive pulmonary disease; emphysema; chronic bronchitis; or kidney disease.
      Four binary measures of Health Related Quality of Life Measures were included: (1) poor/fair general health (reference: good or better health); (2) frequent poor physical health (≥14 days of poor physical health, including physical illness and injury in the prior 30 days); (3) frequent mental distress (≥14 days of poor mental health including stress, depression, and problems with emotions) in the past 30 days; and (4) frequent limitations (≥14 days during which poor physical or mental health led to activity restrictions [such as self-care, work, recreation] in the past 30 days).
      Three of the most prevalent (i.e., >10%) functional types of disabilities were included: disability in mobility (having serious difficulty walking or climbing stairs); disability in cognition (serious difficulty concentrating, remembering, and making decisions because of physical, mental, or emotional conditions); and disability in independent living (having difficulty doing errands alone, such as visiting a doctor’s office or shopping, because of physical, mental, or emotional conditions). The authors defined multiple disabilities as having at least one of the prior three disabilities; disability in vision (being blind or having serious difficulty seeing); or disability in self-care (difficulty dressing or bathing).
      Four health behaviors were examined: no exercise (no physical activity/exercise during the past 30 days other than regular job); current smoking (smoking cigarettes every day or some days); heavy episodic drinking (four [for female sex identified] or five [for male sex identified] or more drinks on at least one occasion in the past 30 days; this variable was assigned based on interviewer or self-reported sex, irrespective of gender identity); and obesity (BMI ≥30).
      Six binary measures of healthcare access and utilization were included: (1) had a routine primary care visit in the past year; (2) had a routine dental visit in the past year; (3) delayed accessing medical care because of cost; (4) has a primary care provider; (5) ever tested for HIV; and (6) influenza vaccine in the past year.

       Statistical Analysis

      Data were pooled and reweighted to be representative of each state in the sample. Survey weights in each year were multiplied by the number of all respondents surveyed in that year divided by the number of respondents surveyed during the period.
      Centers for Disease Control and Prevention (CDC)
      2016 Comparability of BRFSS Data.
      These recalibrated weights were used to calculate the pooled (period) prevalence of the transgender population.
      The weighted distribution of demographic and health variables was estimated for each gender identity group (additional demographic statistics presented in Appendix Table 3 [available online] for individuals who reported don’t know/not sure, refused, or missing); Pearson chi-square tests were used to compare groups.
      Logistic regressions were used to estimate adjusted odds of each health measure for the three TGNC groups, first using CMs as the reference, and then using CFs as the reference. Adjusted models controlled for age, race/ethnicity, relationship status, educational attainment, health insurance coverage, and state of residence. An additional analysis was conducted to estimate the ORs for each TGNC group controlling for age only (Appendix Table 4, available online). All analyses were conducted separately for each outcome using Stata, version 13, with pooled survey weights in February 2018.

      Results

      A total of 525,301 respondents were asked the transgender identity question between 2014 and 2016 in BRFSS, of which 0.48% (95% CI=0.44, 0.53) of respondents identified as transgender. By gender identity, 0.24% (95% CI=0.21, 0.27) identified as MTF, 0.14% (95% CI=0.12, 0.17) identified as FTM, 0.10% (95% CI=0.08, 0.12) identified as GNC; whereas 50.9% (95% CI=50.6, 51.2] were CF, and 47.1% (95% CI=46.8, 47.4) were CM; and 0.60% (n=2,964) of respondents answered they did not know or were not sure, and 0.80% (n=4,281) refused. A higher proportion of young, Latinx, and divorced/separated people reported they did not know or were not sure (Appendix Table 3, available online).
      State-specific proportions of transgender respondents ranged from 0.82% (95% CI=0.58, 1.17) in West Virginia to 0.26% (95% CI=0.13, 0.49) in Wyoming (Figure 1, Appendix Table 2 [available online] provides proportions in remaining sample states).
      Compared with cisgender respondents, transgender respondents were younger, more racially/ethnically diverse, and more likely to identify as lesbian, gay, or bisexual (Table 1). Transgender people had lower educational attainment and income and were more likely to be unemployed, never married, and uninsured. Despite these commonalities, differences between transgender groups existed. Notably, FTM transgender people were the most socioeconomically disadvantaged: This group was the least likely to have a college degree, be homeowners, make >$50,000, or to have health insurance. FTM transgender people were also the most likely to have children living in their household.
      Table 1Demographic Characteristics of Transgender and Cisgender Adults, 2014–2016 BRFSS
      CharacteristicsMale-to-female, %Female-to-male, %Gender-nonconforming, %Cisgender female, %Cisgender male, %
      Total, n (%)1,073 (0.24)699 (0.14)449 (0.10)297,810 (50.91)218,021 (47.11)
      Age, years (p<0.001)
       18–2418.221.426.411.312.9
       25–3413.717.818.515.416.7
       35–4415.622.614.916.016.7
       45–5417.111.28.917.718.1
       55–6420.812.114.717.417.3
       ≥6514.814.814.722.118.3
      Race/ethnicity (p<0.001)
       White56.048.952.062.862.7
       Black13.215.214.611.210.4
       Asian7.63.94.45.84.9
       Other/multiracial4.03.67.12.42.7
       Hispanic/Latinx17.426.020.816.314.0
      Education (p<0.001)
       Less than high school26.927.416.513.114.0
       High school graduate34.239.430.027.730.4
       Some college25.422.635.132.329.0
       College graduate13.09.818.526.826.3
      Income (p<0.001)
       <$15,00017.016.915.810.37.5
       $15,000–$24,99919.220.219.015.112.9
       $25,000–$34,99913.613.99.49.08.7
       $35,000–$49,9999.69.811.711.412.6
       $≥50,00027.522.533.238.446.3
      Employment status (p<0.001)
       Employed56.350.445.150.264.4
       Unemployed8.38.18.05.15.8
       Not looking for work8.715.516.317.85.4
       Retired15.312.418.319.117.6
       Unable to work10.39.711.77.26.0
      Health insurance (p<0.001)
       Insured81.476.084.190.187.0
       Uninsured17.323.113.29.612.4
      Marital status (p<0.001)
       Married/partnered52.543.044.054.457.9
       Divorced/separated/widowed18.022.017.024.415.4
       Never married29.233.937.920.726.2
      Sexual orientation (p<0.001)
       Straight/heterosexual74.669.852.393.194.1
       Lesbian or gay4.011.411.11.22.0
       Bisexual11.510.222.92.41.4
      Homeowner (p<0.001)56.150.257.669.668.4
      At least one child in the household (p<0.001)30.046.426.938.634.4
      Note: 2014–2016 pooled data are weighted; does not sum to 100% because “missing” for each variable was not reported here.
      BRFSS, Behavioral Risk Factor Surveillance System.
      Table 2 shows the prevalence of each health outcome across groups. Table 3 shows the adjusted odds of transgender groups, separately compared with CMs and CFs. Compared with CMs, MTF transgender people had higher odds of diagnosed depression (AOR=2.02, 95% CI=1.52, 2.69); compared with CFs, this group had higher odds of CHD/MI (AOR=2.07, 95% CI=1.37, 3.13) and lower odds of asthma (AOR=0.55, 95% CI=0.39, 0.76). FTM transgender people had higher odds of diagnosed depression than both CMs (AOR=3.14, 95% CI=2.07, 4.77) and CFs (AOR=1.58, 95% CI=1.03, 2.42). They also had higher odds of arthritis (AOR=1.57, 95% CI=1.15, 2.13) and multiple chronic conditions (AOR=1.88, 95% CI=1.32, 2.67) than CMs, and higher odds of CHD/MI (AOR=1.90, 95% CI=1.24, 2.9) than CFs. Compared with both CMs and CFs, GNC transgender people had higher odds of CHD/MI (AOR=2.31, 95% CI=1.10, 4.84, and AOR=6.42, 95% CI=2.33, 17.70, respectively); diagnosed depression (AOR=4.31, 95% CI=2.69, 6.89, and AOR=2.29, 95% CI=1.43, 3.67, respectively); and multiple chronic conditions (AOR=2.90, 95% CI=1.71, 4.93, and AOR=2.16, 95% CI=1.27, 3.68, respectively).
      Table 2Health Outcomes, Health Behaviors, and Healthcare Access and Services by Gender Identity
      CharacteristicsMale-to-female, n (%) (n=1,073)Female-to-male, n (%) (n=699)Gender-nonconforming, n (%) (n=449)Cisgender female, n (%) (n=297,810)Cisgender male, n (%) (n=218,021)
      Chronic conditions
       Multiple conditions611 (48.1)423 (46.7)250 (50.7)165,888 (45.8)104,956 (38.3)
       CHD or MI131 (8.0)72 (6.6)57 (17.8)18,862 (4.8)22,818 (9.0)
       Asthma130 (9.9)117 (13.6)82 (19.1)45,954 (15.8)23,525 (11.4)
       Arthritis350 (24.0)270 (24.3)126 (21.7)116,724 (29.6)63,357 (21.3)
       Diabetes200 (14.5)127 (11.1)66 (13.0)38,060 (10.5)30,395 (11.4)
       Depression243 (24.2)201 (31.1)152 (38.2)65,728 (21.1)29,304 (12.5)
      HRQOL-4 measures
       Poor/fair health260 (18.0)192 (21.0)132 (33.0)55,360 (18.5)37,786 (16.7)
       Poor physical health177 (15.3)142 (13.7)76 (17.1)41,665 (13.0)25,277 (10.7)
       Mental distress153 (15.1)134 (25.2)103 (28.1)33,372 (12.7)17,613 (9.3)
       Limitations131 (22.9)96 (18.7)70 (28.0)27,046 (15.4)16,381 (14.9)
      Disabilities
       Mobility242 (17.6)194 (17.7)105 (19.9)57,564 (15.5)29,814 (11.4)
       Cognition174 (19.2)147 (17.4)110 (32.2)31,029 (11.1)18,387 (8.9)
       Independent living111 (10.2)103 (11.0)81 (20.8)26,269 (7.9)11,439 (5.0)
       ≥1 disability373 (33.0)280 (32.7)193 (45.6)81,435 (24.3)46,186 (19.5)
      Health behavior
       No exercise312 (30.8)251 (38.7)129 (34.1)80,182 (26.2)49,257 (22.4)
       Current smoker213 (45.7)136 (62.3)90 (46.4)41,204 (39.8)35,394 (39.3)
       Heavy episodic drinker160 (42.6)73 (30.5)73 (36.7)25,680 (23.8)39,113 (36.7)
       Obese334 (31.3)232 (26.9)143 (29.0)81,464 (29.6)66,155 (29.9)
      Healthcare access and utilization
       No primary care in prior year254 (29.7)156 (27.4)119 (32.3)60,034 (24.5)59,355 (33.1)
       No dental visit in prior year280 (47.6)165 (39.2)105 (47.1)56,333 (28.6)47,218 (33.8)
       No visit because of cost149 (20.6)94 (26.1)70 (18.7)29,916 (13.5)18,276 (11.2)
       No primary health provider185 (25.3)112 (34.2)90 (23.3)29,565 (15.4)40,102 (25.7)
       Never tested for HIV697 (60.9)448 (56.8)271 (55.3)204,928 (61.9)147,991 (64.6)
       No influenza vaccine in past year612 (63.4)376 (67.4)264 (69.3)148,664 (56.6)122,644 (64.2)
      Note: The proportions (%) are weighted using survey weights for 2014–2016 BRFSS.
      BRFSS, Behavioral Risk Factor Surveillance System; CHD, coronary heart disease; HRQOL, health-related quality of life; MI, myocardial infarction.
      Table 3Adjusted Odds of Health Outcomes, Health Behavior, and Healthcare Access and Utilization by Gender Identity
      VariableMale-to-female (n=1,073)Female-to-male (n=699)Gender-nonconforming (n=449)
      Ref: Cisgender male, AOR (95% CI)Ref: Cisgender female, AOR (95% CI)Ref: Cisgender male, AOR (95% CI)Ref: Cisgender female, AOR (95% CI)Ref: Cisgender male, AOR (95% CI)Ref: Cisgender female, AOR (95% CI)
      Chronic conditions
       Multiple condition1.085 (0.810, 1.453)0.793 (0.592, 1.064)1.876** (1.321, 2.666)1.418 (0.996, 2.019)2.899** (1.706, 4.926)2.159** (1.269, 3.675)
       CHD/MI1.008 (0.666, 1.526)2.068** (1.366, 3.133)0.907 (0.595, 1.382)1.895** (1.240, 2.894)2.305* (1.098, 4.841)6.415** (2.325, 17.702)
       Asthma0.814 (0.587, 1.127)0.545** (0.391, 0.759)1.092 (0.720, 1.657)0.765 (0.502, 1.165)1.549 (0.874, 2.745)0.982 (0.548, 1.759)
       Arthritis1.215 (0.852, 1.734)0.834 (0.584, 1.191)1.566** (1.147, 2.138)1.093 (0.800, 1.494)1.340 (0.759, 2.367)0.919 (0.520, 1.627)
       Diabetes1.129 (0.761, 1.675)1.425 (0.960, 2.116)1.037 (0.740, 1.452)1.333 (0.951, 1.869)1.367 (0.794, 2.353)1.728* (1.003, 2.978)
       Depression2.024** (1.522, 2.693)1.061 (0.796, 1.412)3.141** (2.068, 4.770)1.578* (1.031, 2.416)4.306** (2.690, 6.893)2.290** (1.429, 3.671)
      HRQOL-4 measures
       Poor/fair health0.794 (0.558, 1.129)0.728 (0.511, 1.038)0.968 (0.671, 1.396)0.844 (0.589, 1.210)2.514** (1.432, 4.414)2.189** (1.242, 3.859)
       Poor physical health1.213 (0.836, 1.760)1.026 (0.706, 1.491)1.134 (0.807, 1.595)0.997 (0.709, 1.401)1.831* (1.106, 3.032)1.559 (0.938, 2.589)
       Limitations1.620* (1.063, 2.469)1.624* (1.062, 2.484)1.119 (0.635, 1.973)1.206 (0.685, 2.124)2.598** (1.331, 5.074)2.665** (1.360, 5.222)
       Mental distress1.545* (1.087, 2.196)1.026 (0.721, 1.461)2.864** (1.753, 4.681)1.808* (1.091, 2.996)3.424** (2.053, 5.712)2.139** (1.270, 3.603)
      Disabilities
       Mobility1.454** (1.001, 2.110)1.122 (0.772, 1.632)1.604** (1.125, 2.287)1.250 (0.876, 1.786)2.166*** (1.293, 3.626)1.686* (1.004, 2.833)
       Cognition1.898** (1.347, 2.674)1.434* (1.014, 2.028)1.609* (1.072, 2.415)1.253 (0.833, 1.885)4.689** (2.873, 7.654)3.656** (2.237, 5.975)
       Independent living1.893*** (1.242, 2.889)1.187 (0.773, 1.821)1.943*** (1.323, 2.852)1.262 (0.859, 1.853)5.144*** (3.113, 8.497)3.361** (2.034, 5.554)
       ≥1 disability1.677*** (1.207, 2.330)1.329 (0.955, 1.849)1.700*** (1.173, 2.463)1.403 (0.965, 2.038)3.627*** (2.281, 5.768)2.929** (1.836, 4.675)
      Health behavior
       No exercise1.224 (0.902, 1.659)1.006 (0.740, 1.368)1.850** (1.305, 2.621)1.510* (1.062, 2.147)1.874* (1.090, 3.223)1.583 (0.919, 2.727)
       Current smoker0.969 (0.650, 1.444)1.124 (0.799, 1.582)1.864* (1.083, 3.208)1.616 (0.925, 2.825)1.006 (0.559, 1.812)1.003 (0.630, 1.598)
       Heavy episodic drinker1.148 (0.765, 1.723)1.813** (1.263, 2.603)0.548 (0.281, 1.072)1.032 (0.631, 1.688)0.696 (0.388, 1.248)1.456 (0.886, 2.394)
       Obese0.981 (0.951, 1.011)0.956 (0.686, 1.332)0.941 (0.676, 1.309)0.798 (0.560, 1.137)0.781 (0.548, 1.111)0.985 (0.620, 1.565)
      Healthcare access and services
       No primary care visit0.780 (0.516, 1.180)1.144 (0.755, 1.734)0.625* (0.419, 0.933)0.866 (0.581, 1.292)0.919 (0.591, 1.430)1.392 (0.897, 2.161)
       No dental visit1.369 (0.917, 2.044)1.754** (1.172, 2.626)1.02 (0.567, 1.836)1.328 (0.737, 2.394)1.613 (0.855, 3.043)2.176* (1.153, 4.105)
       No visit because of cost1.612*** (1.065, 2.395)1.159 (0.772, 1.740)2.147** (1.065, 2.395)1.543 (0.880, 2.707)2.147*** (1.051, 3.171)1.368 (0.789, 2.371)
       No primary health provider0.821 (0.528, 1.277)1.551 (0.993, 2.421)1.095 (0.671, 1.786)2.011** (1.226, 3.298)0.774 (0.461, 1.301)1.538 (0.919, 2.575)
       Never tested for HIV0.864 (0.640, 1.166)0.985 (0.728, 1.331)0.847 (0.538, 1.335)0.989 (0.625, 1.564)0.717 (0.466, 1.101)0.842 (0.545, 1.301)
       No flu shot in past year0.872 (0.649, 1.170)1.147 (0.853, 1.542)0.921 (0.658, 1.290)1.235 0.880,1.7341.126 (0.716, 1.772)1.465 (0.929, 2.311)
      Note: Two models (one with cisgender male, one with cisgender female) were fit separately for each outcome were fit separately with survey weights, adjusted for age, race/ethnicity, relationship status, educational attainment, health insurance coverage, and state of residence. Boldface indicates statistical significance (*p<0.05; **p<0.01; ***p<0.001).
      CHD, coronary heart disease; HRQOL, health-related quality of life; MI, myocardial infarction.
      MTF transgender people had higher odds of frequent limitations compared with CMs (AOR=1.62, 95% CI=1.06, 2.47) and CFs (AOR=1.62, 95% CI=1.06, 2.48), and frequent mental distress (AOR=1.55, 95% CI=1.09, 2.20) compared with CMs. FTM transgender people had higher odds of mental distress than CMs (AOR=2.86, 95% CI=1.75, 4.68) and CFs (AOR=1.81, 95% CI=1.09, 3.00). GNC people had odds that were 1.83–3.42 higher than both CMs and CFs, except for poor physical health compared with CFs.
      The three transgender groups had higher odds of the four measured disabilities than CMs. GNC transgender people additionally had higher odds of the four measures than CFs, whereas MTF people had higher odds of reporting disabilities in cognition.
      MTF transgender people did not differ from cisgender people for any health behaviors, except for having higher odds of heavy episodic drinking when compared with CFs (AOR=1.81, 95% CI=1.26, 2.60). FTM transgender people had higher odds of no exercise than CMs (AOR=1.85, 95% CI=1.31, 2.62) and CFs (AOR=1.51, 95% CI=1.06, 2.15), as well as higher odds of currently smoking than CMs (AOR=1.86, 95% CI=1.08, 3.21). GNC people had higher odds of no exercise compared with CMs (AOR=1.87, 95% CI=1.09, 3.22).
      All three transgender groups had higher odds of delaying accessing medical care because of cost than CMs. MTF and GNC transgender people had higher odds of no dental visit compared with CFs. FTM people had lower odds of no primary care visit in the last year than CMs, yet higher odds of not having a primary care provider compared with CFs.

      Discussion

      This is one of the first studies to use a national probability sample to compare a comprehensive panel of health outcomes between transgender and cisgender populations, and the first to examine MTF, FTM, and GNC transgender people to both CMs and CFs. Given that 0.48% of the study sample identified as transgender, this translates to an estimated 1.5 million transgender Americans, of whom 770,000 identify as MTF, 458,000 as FTM, and 332,000 as GNC. These results are similar to prior estimates of the transgender population, which was between 0.35% and 0.53% of the population.
      • Meerwijk E.L.
      • Sevelius J.M.
      Transgender population size in the United States: a meta-regression of population-based probability samples.
      • Winter S.
      • Diamond M.
      • Green J.
      • et al.
      Transgender people: health at the margins of society.
      • Crissman H.P.
      • Berger M.B.
      • Graham L.F.
      • Dalton V.K.
      Transgender demographics: a household probability sample of U.S. adults, 2014.
      • Herman J.L.
      • Wilson B.D.
      • Becker T.
      Demographic and health characteristics of transgender adults in California: findings from the 2015–2016 California Health Interview Survey.
      Consistent with study hypothesis and prior research,
      • Dragon C.N.
      • Guerino P.
      • Ewald E.
      • Laffan A.M.
      Transgender Medicare beneficiaries and chronic conditions: exploring fee-for-service claims data.
      • Herman J.L.
      • Wilson B.D.
      • Becker T.
      Demographic and health characteristics of transgender adults in California: findings from the 2015–2016 California Health Interview Survey.
      • Brown G.R.
      • Jones K.T.
      Mental health and medical health disparities in 5135 transgender veterans receiving healthcare in the Veterans Health Administration: a case–control study.
      • Bockting W.O.
      • Miner M.H.
      • Swinburne Romine R.E.
      • Hamilton A.
      • Coleman E.
      Stigma, mental health, and resilience in an online sample of the U.S. transgender population.
      transgender people experienced a higher burden of poor mental health than cisgender people. This is likely due to minority stress resulting from interpersonal and structural cissexist discrimination. A majority of Americans believe that a person’s gender identity cannot differ from the sex they were assigned at birth, effectively precluding the gender self-determination of transgender people.
      • Brown A.
      Republicans, Democrats Have Starkly Different Views on Transgender Issues.
      Every year, numerous jurisdictions pass or consider bills that discriminate against transgender people. Consistent with previous research, there was variation in mental health outcomes across transgender groups
      • Bockting W.O.
      • Miner M.H.
      • Swinburne Romine R.E.
      • Hamilton A.
      • Coleman E.
      Stigma, mental health, and resilience in an online sample of the U.S. transgender population.
      ; more research is needed to understand the possibly differential impact of local, state, and national anti-discrimination and healthcare provision policies on the mental health of transgender people.
      Transgender people also faced a higher burden of disability than cisgender people. This is consistent with recent findings that 71% of gender-minority Medicare beneficiaries were entitled to disability and experienced more disabilities compared with non–gender minority beneficiares.
      • Dragon C.N.
      • Guerino P.
      • Ewald E.
      • Laffan A.M.
      Transgender Medicare beneficiaries and chronic conditions: exploring fee-for-service claims data.
      These findings highlight the urgent need to understand both the causes of disability among TGNC people and the intersectional experiences of transgender people with disabilities in order to improve culturally competent care.
      FTM and GNC transgender respondents had higher odds of multiple chronic conditions. These groups might face issues in care coordination across systems that are not organizationally linked,
      • Anderson G.
      • Knickman J.R.
      Changing the chronic care system to meet people’s needs.
      such as the medical, supportive care, and disability systems,
      • Anderson G.
      • Knickman J.R.
      Changing the chronic care system to meet people’s needs.
      in addition to discrimination
      • Grant J.M.
      • Mottet L.A.
      • Tanis J.
      • Herman J.L.
      • Harrison J.
      • Keisling M.
      National Transgender Discrimination Survey Report on Health and Health Care.
      and lack of cultural competence in the healthcare setting.
      • Berli J.U.
      • Knudson G.
      • Fraser L.
      • et al.
      What surgeons need to know about gender confirmation surgery when providing care for transgender individuals: a review.
      Transgender people with multiple chronic conditions might be more likely to have an unmet need for caregiving; although 90% of the in-home long-term care are unpaid family or informal caregivers,
      • Adelman R.D.
      • Tmanova L.L.
      • Delgado D.
      • Dion S.
      • Lachs M.S.
      Caregiver burden: a clinical review.
      transgender people experience significant family rejection
      • Grant J.M.
      • Mottet L.A.
      • Tanis J.
      • Herman J.L.
      • Harrison J.
      • Keisling M.
      National Transgender Discrimination Survey Report on Health and Health Care.
      and less social support.
      Although all transgender groups had a higher prevalence of no health insurance (largely consistent with a prior study),
      • Gonzales G.
      • Henning-Smith C.
      Barriers to care among transgender and gender nonconforming adults.
      few differences in preventive care utilization were observed, except for delaying care because of cost compared with CMs. This is consistent with prior research on preventive care in Medicare data
      • Progovac A.M.
      • Cook B.L.
      • Mullin B.O.
      • et al.
      Identifying gender minority patients’ health and health care needs in administrative claims data.
      and could be attributed to more healthcare use among this group compared with cisgender peers. These results differ from a prior estimate using the 2014–2015 BRFSS data that found GNC people reported delaying care because of cost and not having a primary care visit in the last year compared with CFs.
      • Gonzales G.
      • Henning-Smith C.
      Barriers to care among transgender and gender nonconforming adults.
      Research on how health access and insurance varies over time and place is critical.
      Despite being more socioeconomically advantaged than both FTM and MTF transgender people, GNC transgender people experienced the most disparities in health outcomes. It is unclear why this population appears to be at greatest risk of poor health. One possibility is that GNC people are more likely to be perceived as transgender, putting them at greater risk of discrimination and stigma. However, the 2015 U.S. Transgender Survey found that GNC people were least likely to be perceived as transgender by others.
      • James S.E.
      • Herman J.
      The Report of the 2015 U.S. Transgender Survey: Executive Summary.
      Finally, despite reported discrimination and violence against transgender women,
      • Grant J.M.
      • Mottet L.A.
      • Tanis J.
      • Herman J.L.
      • Harrison J.
      • Keisling M.
      National Transgender Discrimination Survey Report on Health and Health Care.
      there were little differences in chronic health conditions or health behaviors of MTF respondents compared with CMs. This is likely to be an artifact of the survey design that was a telephone survey of non-institutionalized adults. Transgender women face deep poverty, homelessness,
      • Grant J.M.
      • Mottet L.A.
      • Tanis J.
      • Herman J.L.
      • Harrison J.
      • Keisling M.
      National Transgender Discrimination Survey Report on Health and Health Care.
      and high rates of incarceration.
      • Reisner S.L.
      • Bailey Z.
      • Sevelius J.
      Racial/ethnic disparities in history of incarceration, experiences of victimization, and associated health indicators among transgender women in the U.S.
      Thus, most marginalized transgender women are likely to be “missing,” which biases the results toward the null. Alternatively, age of transition and chronic disease progression linked to biological sex could have confounded results.

       Limitations

      This study has several limitations. This sample includes a majority, but not all states. However, the population not sampled was demographically similar; therefore, these estimates are likely representative of the U.S. population. Further, until 2016, BRFSS respondents’ sex was attributed by the interviewer using vocal timbre,
      • Riley N.C.
      • Blosnich J.R.
      • Bear T.M.
      • Reisner S.L.
      Vocal timbre and the classification of respondent sex in U.S. phone-based surveys.
      which limits the ability to identify biological sex (only in 2016 were respondents asked to report their sex). This means that sex-specific variables, such as alcohol use, might be more inaccurate for transgender participants. Next, it would have been informative to compare respondents’ sex at birth, gender expression, and stigma over the life course.
      Another limitation is that BRFSS did not include any questions about transgender-specific health care, which prohibited this study from describing differences in these healthcare experiences by gender identity. Finally, it is plausible that the manner in which gender identity was assessed created exposure misclassification bias, whereby some respondents with gender-minority identities other than those included in BRFSS might have been misclassified as cisgender, refused to answer, or did not know/were not sure. National surveys should consider following Gender Identity in U.S. Surveillance Group recommendations.
      • Reisner S.L.
      • Conron K.J.
      • Baker K.
      • et al.
      “Counting” transgender and gender-nonconforming adults in health research recommendations from the Gender Identity in U.S. Surveillance Group.

      Conclusions

      Despite these limitations, these findings are important for clinicians seeking to understand how to prevent and detect chronic diseases early in transgender patients, address issues of healthcare access and coordination of care, and improve cultural competency for transgender patients.

      Acknowledgments

      No financial disclosures were reported by the authors of this paper.

      SUPPLEMENTAL MATERIAL

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