Introduction
Latino men have been drastically under-represented in research to identify effective
behavioral weight-loss interventions. This trial compared 2 interventions for weight
loss: (1) a culturally adapted intervention (HOMBRE) and (2) a minimal-intensity intervention.
Design
Randomized controlled trial.
Setting/Participants
Latino men with a BMI ≥27 kg/m2 and 1 or more cardiometabolic risk factors (N=424) were recruited (February 15, 2017‒October
2, 2018) from 14 medical centers and randomized to receive 1 of the 2 interventions.
Intervention
HOMBRE provided men a choice among 3 options: coach-facilitated group sessions using
online video conferencing, coach-facilitated group sessions in person, and prerecorded
videos of group sessions available online.
Main Outcome Measures
The primary outcome was the proportion of participants sustaining clinically significant
(≥5% of baseline) weight loss at 18 months. Secondary outcomes included weight loss
trajectory over time, 3% and 10% weight loss, cardiometabolic risk factors, health
behaviors, and psychosocial well-being at baseline and 18 months. Data were analyzed
from October 6, 2020 to January 15, 2022.
Results
Participants were predominantly middle aged (47.0 [SD=11.9] years), were married (74.3%),
were with at least some college experience (79.7%), and had middle to upper incomes
(72.4% with annual family incomes >$75,000). Their average BMI was 33.1 kg/m2 (SD=5.1). The proportion achieving clinically significant weight loss at 18 months
was 27.4% in the HOMBRE intervention and 20.6% in the minimal-intensity intervention
(mean difference=7.2%, 95% CI= −1.8, 17.0; p=0.13). Mean difference between the HOMBRE vs the minimal-intensity group was ‒1.25
kg at 6 months (95% CI= −2.28, −0.21; p=0.02) and ‒1.11 kg at 12 months (95% CI= −2.11, −0.10; p=0.03) using weight measurement data abstracted from the Electronic Health Record
and by self report. There were no significant differences in secondary outcomes.
Conclusions
Among Latino men with overweight and obesity, HOMBRE was not more effective for clinically
significant weight loss than a minimal-intensity intervention at 18 months.
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Article Info
Publication History
Published online: May 30, 2022
Publication stage
In Press Journal Pre-ProofFootnotes
Trial Registration: This study is registered at www.clinicaltrials.gov NCT03092960.
Identification
Copyright
© 2022 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
