The recent article by Blake et al.1 highlights the important gaps in awareness and knowledge about human papillomavirus (HPV), its relationship with cancer, and the HPV vaccine in the U.S. population. As noted by the authors, the introduction of a health technology can lead to health inequalities if there is differential learning among population subgroups, the so-called “Knowledge Gap Hypothesis.” Comparisons with previous analyses of the Health Information and National Trends Survey (HINTS) suggest awareness has increased among the U.S.