The meta-analysis reported in the three Guide to Community Preventive Services papers published in this issue of the American Journal of Preventive Medicine1–3 targets two basic prevention strategies—comprehensive risk reduction (CRR) and abstinence education—which have the common purpose of lowering adolescent sexual risk behavior. Meta-analyses were conducted for each strategy on key behavioral and biological outcomes. This study did a commendable job of identifying the available studies of sexual risk-reduction interventions and evaluating them according to criteria for study quality.