Patterns of youth tobacco use in the U.S. are becoming increasingly complex with the greater availability, marketing, and promotion of a diverse set of tobacco products. Using data from the 2012 National Youth Tobacco Survey (NYTS), the series of papers in this issue present a multifaceted examination of the attitudes and behaviors surrounding the diversity of tobacco products with a nationally representative sample of middle and high school students. Taken together, these papers represent one of the most comprehensive pictures of adolescent tobacco use in the U.S.