Ending the tobacco epidemic represents an aspirational, yet achievable, public health vision for our nation. Fulfilling that vision requires national commitment and collaboration. To date, the nation has certainly witnessed much progress, with adult cigarette use prevalence dropping by more than 50% from the peak levels of the 1960s.1,2 But tobacco dependence remains the leading preventable cause of mortality in our country, causing more than 400,000 deaths annually. To accelerate progress, we need a greater commitment to action and science than ever before.