The use of e-cigarettes, or electronic nicotine delivery systems, has increased among U.S. adolescents during the past few years.1,2 In 2019, more than 1 in 4 adolescents in high school indicated using e-cigarettes during the past 30 days, an increase of 38% from 2018.1,3 The increase in past 30–day rates of e-cigarette use is concerning, given that there is growing evidence that e-cigarette use, along with the frequency of e-cigarette use, is associated with symptoms of nicotine dependence among adolescents.